High performance NGS panel for every application

At Paragon Genomics, we understand that every researcher and assay developer has different challenges and requirements. This is why we offer the highest level of flexibility to our customers to support their specific applications. Most importantly, we deliver high quality custom NGS panels to help customers accomplish what they set out to do, whether it’s answering a research question, replacing an existing laborious hybrid-capture workflow, or deploying a new genetic test. 

Selected Delivered Projects

Hear from Our Satisfied Customers

Top Research Labs in the US

Application: SARS-CoV-2 Surveillance in Wastewater

Challenge: Low quality and low quantity RNA samples, Specificity

“We have used the CleanPlex SARS-CoV-2 Panel for our COVID-19 wastewater surveillance program in Southern Nevada. The NGS panel has provided high sequencing coverage for emerging variants in our community and we are pleased with the ease and consistency of the workflow and results, respectively”

Edwin Oh, Ph.D. Associate Professor, Neurogenetics and Precision Medicine Lab, Nevada Institute of Personalized Medicine
Case Western

Top Research Labs in the US

Application: SARS-CoV-2 Surveillance

Challenge: Accurate Variant Calling

“The laboratory, bioinformatics and administrative staff at Paragon Genomics have helped save time and effort on numerous occasions during our COVID-19 project development. Supportive collaboration with PG has played an integral role in learning more about the transmission dynamics of this dangerous new coronavirus.”

Note: Prof. Peter Zimmerman, Dr. Ricky Chan and Dr. Curtis Donskey and their research team members at Case Western Reserve University and the Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, Ohio have used Paragon’s CleanPlex SARS-CoV-2 and FLEX Panel to perform outbreak investigations involving hospital staff, patients and support personnel. Studies published to-date have investigated COVID-19 outbreaks in the VA Hospital Emergency Department (PMID: 33941299 DOI: 10.1017/ice.2021.208) and virus transmission during patient transport in commuter vans (PMCID: PMC8135457).

Peter Zimmerman, PhD, Professor, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Department of Medicine

Top Hospital in the US

Application: SARS-CoV-2 Detection

Challenge: Low RNA Input

I was very impressed by how well the CleanPlex SARS-CoV-2 panel worked when we evaluated it back in March. Working with Paragon Genomics, we were able to leverage the panel to quickly launch a SARS-CoV-2 whole-genome sequencing assay and used it effectively for a number of genomic epidemiology studies. As a human geneticist and informaticist, I am also excited about the availability of the CleanPlex ACE2/TMPRSS2 germline + eQTL panel. We have sequenced thousands of positive COVID 19 samples, which revealed a tremendous amount of viral genetic diversity. It is therefore most interesting now to study the host genetic variants, especially in the ACE2 and TMPRSS2 genes that are the two most essential genes for SARS-CoV-2 infection. The interplay of human host genetic variants in these genes, along with the SARS-CoV-2 mutations and haplotypes, may well determine how severe the infection is and the resulting clinical phenotypes.

Xiaowu Gai, PhD, Director of Bioinformatics, Children's Hospital Los Angeles

Top genomics research institute in the US

Application: Identification of RNA Virus Minor Variants

Challenge: Design Amplicons Against Many Variants

We’re using Paragon’s CleanPlex and CleanPlex UMI technologies to sequence RNA viruses. These technologies enable us to rapidly and cost-effectively obtain complete viral genomes from clinical samples with low viral content. Further analyses of viral genomes, including the identification of minor variants, elucidates viral diversity and evolution. Paragon has enthusiastically worked with us to tackle this new application; they have diligently designed panels to our specifications, meeting with us frequently to optimize the design.
Aaron Lin, PhD; Erica Normandin; Kim Lagerborg, Broad Institute of MIT and Harvard

Top-ten medical center in the US

Application: Mutational Burden Analysis

Challenge: Development of in-house NGS-based assays

When we decided to choose a sequencing platform, we had several choices and I am delighted that we chose Paragon Genomics. Paragon Genomics has enabled us to move our sequencing in-house with an affordable and easy-to-use product. They assisted us every step along the way from choosing the amplicons, to guiding us through library preparation to assisting with analysis. I strongly recommend their CleanPlex® amplicon-based targeted sequencing approach and could not be happier with their product.
Elliot Stieglitz, MD, Assistant Professor, University of California San Francisco

Top-three commercial NGS lab in China

Application: Cancer Testing

Challenge: Uniformity and on-target rate of NGS libraries

Paragon Genomics designed a high-quality NGS custom panel for us within two weeks. Its CleanPlex® targeted library technology is fast and easy to use with great PCR uniformity and on-target rate. We are very satisfied by CleanPlex product performance and the superb technical and customer support provided by the Company.

Chongjian Chen, PhD, CEO, Annoroad

Major NGS service provider in Turkey

Application: Inherited Disease Testing

Challenge: Turn-around time of custom NGS panels

As a service provider and distributor company, it is crucial for us to fulfill inquiries coming from our customer in a fast and reliable manner. Paragon Genomics’ custom design and production pipeline has shown itself very useful to expand our portfolio and services in a very short time. Their CleanPlex® assays are robust and work directly from the start with a uniform coverage distribution and the ability to design single gene or small gene panels as well as larger panels makes CleanPlex a flexible tool.

Damla Erdogan, Business Development Manager, Gen Era Diagnostics

Federal agricultural research agency in the US

Application: AgBio

Challenge: Quality DNA samples

We are looking for a ‘future proof method’, a better way to do high throughput screening at a species level diagnosis. Paragon Genomics has developed a rapid 2.5-hour library preparation allowing multi-gene methodology, letting us look at lots of unique loci across multiple genomes. It offers a ‘one and done’ approach instead of many different disconnected experiments.

Scott Geib, PhD, Research Entomologist, USDA-ARS

Fruit and vegetable industries in the continental US are under constant threat by invasive pest fruit flies, many of which cannot be identified using morphology alone. When flies or their larvae are intercepted, regulatory agencies need to quickly identify what species they are dealing with and where they came from. USDA-ARS and University of Hawaii are developing genomic tools for these tasks. Paragon Genomics’ CleanPlex® technology allows us to target thousands of highly-informative genomic regions is a single panel, thus integrating species identification and source determination. The 2.5-hour library preparation time combined with robust reaction chemistry for low quality samples means that these tools can be used quickly and efficiently.

Julian R. Dupuis, PhD, Junior Faculty, University of Hawaii at Manoa and USDA-ARS

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