The Old Fight is New: Tackling Malaria with Next-Generation Sequencing

Bryan_Greenhouse

A new modular targeted NGS panel from UCSF, developed in collaboration with Paragon Genomics, empowers researchers worldwide to explore the genome of P. falciparum, the parasite causing malaria. With 241 million cases annually, primarily in Africa, malaria remains a significant health and economic burden. Advances in sequencing technology have revolutionized malaria research, enabling detailed studies on genetics, transmission, and drug resistance. Led by Dr. Bryan Greenhouse and supported by the Bill and Melinda Gates Foundation and NIH, UCSF’s efforts in molecular surveillance aim to adapt to evolving challenges and enhance global epidemiological studies, promising transformative impacts on malaria research and control.

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A Multiplexed High Throughput Method to Evaluate Novel Nuclease Activity (in collaboration with Synthego)

Paragon Genomics targeted sequencing technology and Synthego’s expertise in CRISPR have been combined to develop a new method to evaluate novel nucleases that enables direct comparison of their editing activity. This white paper takes a closer look at this collaboration displaying the power of Synthego’s Halo™ Platform for Synthetic sgRNA and automation capabilities coupled with Paragon Genomics CleanPlex™ amplicon sequencing technology to have a side-by-side comparison of the activity of nucleases. Read the full white paper to see the data and discover the benefits of using the technology together for CRISPR QC. 

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Accurate Detection and Whole Genome Characterization of SARS-CoV-2 using CleanPlex® SARS-CoV-2 Research and Surveillance Panel

TN1009_SARS-CoV-2 Panel TN1009 SARS-CoV-2 Panel Technical Note

In this technical note, we demonstrate that the Paragon Genomics’ SARS-CoV-2 Panel with NGS sequencing can provide nucleic acid-level information for strain identification, inter and intra-host mutation analysis, phylogenetic analysis for surveillance and tracking, and ultimately advance vaccine development, thereby paving the way for our better understanding of this virus and helping the scientific community to fight this pandemic together. Read the full report and discover the benefits of using CleanPlex SARS-CoV-2 Panel for your COVID-19 research and surveillance projects. 

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A High-Performance Solution Combining CleanPlex® OncoZoom® Cancer Hotspot Panel and SOPHiA™ AI for Rapid Characterization of Somatic Mutations

In this technical note, experts from SOPHiA GENETICS compared CleanPlex to other target enrichment technologies and found CleanPlex to provide the highest coverage uniformity. Read the full report and discover the benefits of combining CleanPlex with SOPHiA AI for a complete genomics solution. 

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CleanPlex® Technology: Ultrafast, Simple, and Scalable Targeted Sequencing Solution for All Sequencing Platforms

This technical note provides an overview to different targeted sequencing approaches and introduces our flagship CleanPlex technology, including its sequencing performance. 

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