CleanPlex® Amplicon-Based NGS Panels for Amplicon Sequencing

Comprehensive NGS Target Enrichment Solution

High Quality Rapid Workflow Customizable

What is CleanPlex Technology?
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Scientist pipetting a sample into a tube in a sequencing lab

Application Markets

Use Paragon Genomics CleanPlex Kits for genomic testing, entire genome amplification, or research projects. These kits can be applied to areas such as infectious disease, precision oncology, inherited disease, and molecular breeding.

Multiplex PCR-based Target Enrichment and Library Preparation Methods

CleanPlex amplicon sequencing for DNA and RNA-Seq

CleanPlex Amplicon Sequencing for DNA and RNA-Seq

  • 3-hour workflow
  • Low DNA/RNA input
  • Up to 20,000 amplicons per pool
  • Unique PCR background cleaning

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CleanPlex UMI kit

CleanPlex UMI (Unique Molecular Identifier) for Low-Frequency Allele Detection

  • 3.5-hour workflow
  • PCR/Sequencing error correction
  • Ultra sensitivity (0.1%)

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AccuFusion RNA gene fusion detection

AccuFusion™ RNA Gene Fusion Detection

  • 6-hour workflow
  • Detect RNA gene fusions
  • Optimized reverse transcription
  • Built on CleanPlex DNA technology

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1600+ Custom Next-Generation Sequencing (NGS) Panels Delivered to 500+ NGS Labs

Design an NGS Panel
Custom Panel Consultation
Ready-to-Use NGS Assays

Testimonials on CleanPlex and CleanPlex UMI NGS Kits

Elliot Stieglitz, MD

Affordable and easy-to-use product

“When we decided to choose a targeted sequencing platform, we had several choices and I am delighted that we chose Paragon Genomics. Paragon Genomics has enabled us to move our sequencing in-house with an affordable and easy-to-use product. They assisted us every step along the way from choosing the amplicons, to guiding us through library preparation to assisting with analysis. I strongly recommend their CleanPlex® amplicon-based targeted sequencing approach and could not be happier with their product.”

Elliot Stieglitz, MD Associate Professor, University of California San Francisco

Xiaowu Gai, PhD

I was very impressed by how well the CleanPlex SARS-CoV-2 panel worked

“I was very impressed by how well the CleanPlex SARS-CoV-2 panel worked when we evaluated it back in March. Working with Paragon Genomics, we were able to leverage the panel to quickly launch a SARS-CoV-2 whole-genome sequencing assay and used it effectively for a number of genomic epidemiology studies.”

Xiaowu Gai, PhD Director of Bioinformatics, Children's Hospital Los Angeles

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Who’s Choosing CleanPlex NGS Panels

300+ organizations globally are partnering with Paragon Genomics as their NGS assay partner, using CleanPlex NGS panels and custom NGS panels for their targeted sequencing applications.

  • Broad Institute
  • MD Anderson Cancer Center
  • Mayo Clinic
  • Icahn School of Medicine at Mount Sinai
  • Novartis
  • USDA
  • Boston Children's Hospital
  • St. Jude Children's Research Hospital
  • Children's Hospital Los Angeles
  • National Institutes of Health
  • Interpace Diagnostics
  • Sophia Genetics
  • Robert Koch Institut
  • Berry Genomics
  • Dian Diagnostics

Customer Spotlight:

“We spent a couple of years researching and testing different technologies, but we couldn’t find one that worked for both sensitivity and throughput until we met Paragon Genomics.” – Dr. Greenhouse

This customer spotlight features Professor Bryan Greenhouse of UCSF and his lab’s efforts to build out their genomic surveillance infrastructure to transform the landscape of malaria research. Their modular community panel, developed with Paragon Genomics, empowers researchers across the world to take a deep-dive into the genome of P. falciparum. Read the piece below to hear more about Dr. Greenhouse’s personal story, scope of research, and how his lab has harnessed the power of the panel to answer questions related to population genetics, transmission dynamics, and drug resistance surveillance.

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Tackling Malaria with Next-Generation Sequencing, customer spotlight with Dr. Bryan Greenhouse