CleanPlex SARS-CoV-2 Emerging Variants Panel Add-on v2 for robust whole-genome coverage

The new variants of concern, particularly the recently discovered Omicron variant from South Africa contain mutations in the receptor-binding domain (RBD) of the spike protein, which have been shown to significantly increase infection rates and can negatively impact the efficacy of the recently developed vaccines and current COVID-19 qPCR mass testing methods. Thus, a robust detection method and continued screening and surveillance are more critical than ever in our continued global efforts to control this pandemic.

The Emerging Variants Panel Add-on v2 has been specifically optimized from the initial product to address the emerging variants by targeting the unique mutations in the S gene, and by cross-referencing the FLEX panel design for uniform coverage and confident identification of their defining mutations. EVA v2 has been confirmed in-silico to cover all defining and characteristic mutations of the sub-lineages of omicron: BA.1, BA.2, BA. 2.12.1, BA. 2.75, BA.3, BA. 4, and BA.5. 

The CleanPlex SARS-CoV-2 Panel has repeatedly demonstrated consistently high coverage of multiple variants. Read more about how the panel has been used around the globe for surveillance and research.

Highlights of the Add-on v2 Panel

• • Robust Coverage
    Added primers for enhanced coverage of newly discovered variants and their sub-lineages such as Omicron, Delta, Mu, Beta, and Alpha 
  • Additional Confidence in Variant Calling
    Optimized for identifying existing and new mutations for surveillance and tracking, especially with ”super-amplicon” formation in base panels
  • Easy Spike-in Workflow
    Directly add to existing CleanPlex SARS-CoV-2 and FLEX panels for ease of use and flexible future updates.

The SARS-CoV-2 Emerging Variant Panel Add-on v2 is designed to be used with the existing CleanPlex SARS-CoV-2 products to maintain high coverage for variant calling and identification as the virus evolves. Follow the links here to learn more about the Original CleanPlex SARS-CoV-2 and FLEX Panels. The CleanPlex SARS-CoV-2 Kits contains the CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit with RT components. CleanPlex Indexed PCR Primers for sample pooling and CleanMag^® Magnetic Beads for bead purification and size selection are ordered separately to complete the workflow from input RNA to sequencing-ready NGS libraries.

For a complete solution, please use the following indexed PCR primers and magnetic beads SKUs.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.