The CleanPlex® Pediatric Cancer Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 66 genes associated with Pediatric Cancer.
CleanPlex® Pediatric Cancer Panel
The CleanPlex® Pediatric Cancer Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 66 genes associated with Pediatric Cancer. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
AIP, ALK, APC, ATM, AXIN2, BAP1, BLM, BMPR1A, BUB1B, CDC73, CDKN1C, CEBPA, DICER1, DIS3L2, EPCAM, ETV6, EXT1, EXT2, FH, GATA2, GPC3, HRAS, KIF1B, LZTR1, MAX, MEN1, MLH1, MSH2, MSH6, NBN, NF1, NF2, PAX5, PHOX2B, PMS2, PRF1, PRKAR1A, PTCH1, PTCH2, PTEN, RB1, RECQL4, REST, RET, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, SMARCE1, SRP72, STK11, SUFU, TERC, TERT, TMEM127, TP53, TSC1, TSC2, VHL, WRN, WT1
Ahmed AA, et al. Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects. High Throughput. 2018;7(4):39.
Khater F, et al. Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers. JAMA Netw Open. 2019;2(4):e192906.
Khan J, et al. Precision Therapy for Pediatric Cancers. JAMA Oncol. 2016;2(5):575–577.
Kuhlen M, et al. Family-based germline sequencing in children with cancer. Oncogene 38, 1367–1380 (2019).
Maese L, et al. The evidence for expanded genetic testing for pediatric patients with cancer. Future Oncol. (2018) 14(3), 187–190
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|