CleanPlex® Comprehensive Hereditary Cancer Panel

$1,240.00$97,880.00

The CleanPlex® Comprehensive Hereditary Cancer Panel is a pre-designed and stocked multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 88 genes associated with Comprehensive Hereditary Cancer.

Product Description

The CleanPlex® Comprehensive Hereditary Cancer Panel is a pre-designed and stocked multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 88 genes associated with Comprehensive Hereditary Cancer. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

The panel kit contains CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Paragon Genomics has partnered with VarSome Clinical to provide a full solution for fast and accurate variant discovery, annotation, and interpretation of next-generation sequencing data for targeted gene panels. Click here to find out more!

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
AIP, ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK4, CDKN1B, CDKN1C, CDKN2A, CEBPA, CHEK2, DICER1, DIS3L2, EGFR, EPCAM, FANCC, FANCM, FH, FLCN, GATA2, GPC3, GREM1, HNF1A, HOXB13, HRAS, KIT, MAX, MEN1, MET, MITF, MLH1, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, PALB2, PDGFRA, PHOX2B, PMS1, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RB1, RECQL, RECQL4, RET, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SMARCB1, STK11, SUFU, TERC, TERT, TMEM127, TP53, TSC1, TSC2, VHL, WRN, WT1, XRCC2

References:
Kurian AW, et al. Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment. J Clin Oncol. 2014 Jul 1;32(19):2001-9.

Additional Information

Weight40 g
Dimensions10 × 7 × 5 cm
Pack Size (Reactions)

96 MGI, 384 MGI, 1152 MGI, 8 Illumina, 96 Illumina, 384 Illumina

CleanPlex Amplicon Sequencing Library Kit Product ImageCleanPlex® Comprehensive Hereditary Cancer Panel
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