CleanPlex® Bone Marrow Failure Syndromes Panel

The CleanPlex® Bone Marrow Failure Syndromes Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 89 genes associated with Bone Marrow Failure Syndromes.

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Product Description

The CleanPlex® Bone Marrow Failure Syndromes Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 89 genes associated with Bone Marrow Failure Syndromes. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
ACD, AK2, ANKRD26, AP3B1, ATM, BLM, BRCA1, BRCA2, BRIP1, CBL, CEBPA, CSF3R, CTC1, CXCR4, DDX41, DKC1, DNAJC21, ELANE, EPCAM, ERCC4, ETV6, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, G6PC3, GATA1, GATA2, GFI1, HAX1, IKZF1, LAMTOR2, LYST, MLH1, MPL, MSH2, MSH6, NBN, NF1, NHP2, NOP10, PALB2, PAX5, PMS2, PTPN11, RAB27A, RAC2, RAD51C, RBM8A, RMRP, RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10, RPS17, RPS19, RPS24, RPS26, RPS28, RPS29, RPS7, RTEL1, RUNX1, SAMD9, SAMD9L, SBDS, SLC37A4, SLX4, SRP72, TAZ, TERC, TERT, TINF2, TP53, UBE2T, USB1, VPS13B, VPS45, WAS, WRAP53, XRCC2

References:
Mehta PA, Tolar J. Fanconi Anemia. Gene Reviews. Pagon RA, Adam MP, Ardinger HH, et al., editors. Seattle (WA): University of Washington, Seattle; 1993-2016.

Dokal I, Vulliamy T, Mason P, Bessler M. Clinical utility gene card for: Dyskeratosis congenita–update 2015. European Journal of Human Genetics. 2015 Apr;23(4).

Alter BP, Giri N, Savage SA, Peters JA, Loud JT, Leathwood L, Carr AG, Greene MH, Rosenberg PS. Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study. British journal of haematology. 2010 Jul;150(2):179-88.

Additional Information

Weight40 g
Dimensions10 x 7 x 5 cm
Pack Size (Reactions)

1000

For early access to our upcoming Respiratory Research Panel combining Influenza A/B and SARS-CoV-2 testing, please visit HERE. Dismiss