The CleanPlex® Parkinson Disease Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 36 genes associated with Parkinson Disease.
CleanPlex® Parkinson Disease Panel
The CleanPlex® Parkinson Disease Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 36 genes associated with Parkinson Disease. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
ATP13A2, ATP1A3, ATP6AP2, ATP7B, C19orf12, CHCHD2, DCTN1, DNAJC6, EIF4G1, FBXO7, GBA, GCH1, HTRA2, LRRK2, MAPT, PARK2, PARK7, PINK1, PLA2G6, POLG, PRKN, PRKRA, RAB39B, SLC20A2, SLC6A3, SNCA, SPR, SYNJ1, TAF1, TH, UCHL1, VPS13A, VPS13C, VPS35, WDR45, XPR1
Devanna,P, et al. Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders. Mol Psychiatry 23, 1375–1384 (2018).
Farlow JL, et al. Whole-Exome Sequencing in Familial Parkinson Disease. JAMA Neurol. 2016;73(1):68–75.
Robak L, Excessive buyrden of lysosomal storage disorder gene variants in Parkinson’s disease. Brain. (140)12:3191–3203.
Zucca S, et al. Analysis of amplicon-based NGS data from neurological disease gene panels: a new method for allele drop-out management. BMC Bioinformatics 17, 339 (2016).
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|