CleanPlex® Hereditary Myelodysplastic Syndrome (MDS) /Leukemia Panel

The CleanPlex® Hereditary Myelodysplastic Syndrome (MDS) /Leukemia Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 22 genes associated with Hereditary Myelodysplastic Syndrome (MDS) /Leukemia.

Product Description

The CleanPlex® Hereditary Myelodysplastic Syndrome (MDS) /Leukemia Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 22 genes associated with Hereditary Myelodysplastic Syndrome (MDS) /Leukemia. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
ANKRD26, ATM, BLM, CEBPA, DDX41, EPCAM, ETV6, GATA2, HRAS, MLH1, MSH2, MSH6, NBN, NF1, PMS2, RUNX1, SAMD9, SAMD9L, SRP72, TERC, TERT, TP53

References:
Feurstein S, et al. Genetic predisposition to leukemia and other hematologic malignancies. Seminars in Oncology. 2016;43(5):598-608.

Babushok DV, et al. Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults. Leukemia & Lymphoma. 2016;(57)3: 520-536.

Bräuninger A, et al.Targeted Next-Generation Sequencing Is a Sensitive Tool for Differential Diagnosis of Myelodysplastic Syndromes in Bone Marrow Trephines. The Journal of Molecular Diagnostics. 2018; (20)3:344-354.

Additional Information

Weight40 g
Dimensions10 x 7 x 5 cm
Pack Size (Reactions)

384