The CleanPlex® Hereditary Motor Neuropathy Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 20 genes associated with Hereditary Motor Neuropathy.
CleanPlex® Hereditary Motor Neuropathy Panel
The CleanPlex® Hereditary Motor Neuropathy Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 20 genes associated with Hereditary Motor Neuropathy. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
ATP7A, BICD2, BSCL2, DCTN1, DNAJB2, DYNC1H1, FBXO38, GAN, GARS, HINT1, HSPB1, HSPB3, HSPB8, IGHMBP2, PLEKHG5, REEP1, SETX, SIGMAR1, SLC5A7, TRPV4
Previtali SC, et al. Expanding the spectrum of genes responsible for hereditary motor neuropathies. J Neurol Neurosurg Psychiatry. 2019 Oct;90(10):1171-1179.
Chen B, et al. Clinical, electrophysiological, genetic, and imaging features of six Chinese Han patients with hereditary neuropathy with liability to pressure palsies (HNPP). J Clin Neurosci. 2018 Feb;48:133-137.
Bacquet J, et al. Molecular diagnosis of inherited peripheral neuropathies by targeted next-generation sequencing: molecular spectrum delineation. BMJ Open. 2018 Oct 28;8(10):e021632.
Hoyle JC, et al. The genetics of Charcot-Marie-Tooth disease: current trends and future implications for diagnosis and management. Appl Clin Genet. 2015 Oct 19;8:235-43.
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|