The CleanPlex® Rett and Angelman Syndromes Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 18 genes associated with Rett and Angelman Syndromes.
CleanPlex® Rett and Angelman Syndromes Panel
The CleanPlex® Rett and Angelman Syndromes Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 18 genes associated with Rett and Angelman Syndromes. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
ATRX, CDKL5, CNTNAP2, FOXG1, GABBR2, IQSEC2, MBD5, MECP2, MEF2C, NRXN1, SATB2, SCN8A, SLC9A6, STXBP1, TCF4, UBE3A, WDR45, ZEB2
Vidal S, et al. Genetic Landscape of Rett Syndrome Spectrum: Improvements and Challenges. Int. J. Mol. Sci. 2019, 20(16), 3925.
Vidal S, et al. The utility of Next Generation Sequencing for molecular diagnostics in Rett syndrome. Sci Rep. 2017 Sep 25;7(1):12288.
Wang J, et al. Rett and Rett-like syndrome: Expanding the genetic spectrum to KIF1A and GRIN1 gene. Mol Genet Genomic Med. 2019 Nov;7(11):e968.
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|