CleanPlex® Left Ventricular Noncompaction (LVNC) Panel

The CleanPlex® Left Ventricular Noncompaction (LVNC) Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 39 genes associated with Left Ventricular Noncompaction (LVNC).

Product Description

The CleanPlex® Left Ventricular Noncompaction (LVNC) Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 39 genes associated with Left Ventricular Noncompaction (LVNC). The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
ABCC9, ACTC1, ACTN2, BAG3, CTNNA3, DES, DMD, DSC2, DSG2, DSP, DTNA, EMD, FLNC, HCN4, JPH2, JUP, LAMP2, LDB3, LMNA, MIB1, MYBPC3, MYH6, MYH7, NEXN, PKP2, PLEKHM2, PLN, PRDM16, RAF1, RBM20, RYR2, SCN5A, TAZ, TCAP, TNNI3, TNNT2, TPM1, TTN, VCL

References:
Oechslin E, et al. Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? Eur Heart J. 2011 Jun;32(12):1446-56.

Ichida F, et al. Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation. 2001 Mar 6;103(9):1256-63.

Additional Information

Weight40 g
Dimensions10 × 7 × 5 cm
Pack Size (Reactions)

384

CleanPlex Amplicon Sequencing Library Kit Product ImageCleanPlex® Left Ventricular Noncompaction (LVNC) Panel