Medical research centers need reliable tools that help them study genetic variation, investigate cancer pathways, and understand how patients respond to treatment. At Paragon Genomics, our targeted amplicon-based NGS panels give your team the power to analyze TP53 variants, evaluate key pharmacogenes, and detect lung cancer fusion events with accuracy and speed across Illumina and MGI platforms. These solutions support precision medicine programs, therapeutic development, and large-scale genomic studies that drive stronger outcomes in clinical and translational research.
Product Highlights
CleanPlex TP53 Kit
The CleanPlex® TP53 Kit is a multiplex PCR-based targeted resequencing assay designed to simplify the evaluation of somatic and germline variants across the TP53 gene.
CleanPlex Pharmacogenomics Kit
The CleanPlex® Pharmacogenomics Kit is a single assay that analyzes twenty-eight key pharmacogenes across major drug metabolism pathways, including CYP450s, with a full assessment of the CYP2D6 gene copy number, as well as transporters and drug targets. The panel supports research in cardiology, psychiatry, pain management, and oncology by giving teams clear, actionable insights that strengthen their work across multiple therapeutic areas.
AccuFusion RNA Lung Cancer Kit
AccuFusion® RNA Lung Cancer Kit uses a dual primer amplification method to enable focused detection of more than 280 known gene fusions associated with non-small cell lung cancer (NSCLC). Fusion genes are associated with ALK, CIT, EML4, FGFR1, MBIP, MET, NRG1, NTRK1, NTRK3, PDGFRA, RET, ROS1, TACC3.
NGS Custom Panel
Over 1600 Custom NGS Panels, including both DNA and RNA assays, have been designed and shipped to NGS labs around the world. Medical research centers use these custom panels for a wide range of projects, including tumor profiling, cancer liquid biopsy, pharmacogenomics, neurology, cardiology, infectious disease, food safety, and agrigenomics.
Examples of Amplicon-Based NGS for Medical Research Centers
NGS for TP53 Variant Analysis
Medical research centers studying cancer biology use the CleanPlex TP53 Kit to evaluate somatic and germline variants across the full TP53 gene. This multiplex PCR assay helps laboratories investigate tumor behavior, assess genomic instability, and deepen their understanding of pathways that shape patient outcomes in oncology research and human biology.
NGS for Pharmacogenomics Studies
Medical research centers rely on the CleanPlex Pharmacogenomics Kit to examine how genetic variation influences medication response. This single assay analyzes twenty-eight key pharmacogenes across major drug metabolism pathways, giving dedicated research teams clear insights that support basic research, therapeutic development, and new treatments that improve patient health and advance modern healthcare.
NGS for Lung Cancer Fusion Detection
Researchers focused on non-small cell lung cancer use the AccuFusion RNA Lung Cancer Kit to detect more than 280 known gene fusions linked to tumor growth. The dual primer amplification method allows accurate identification of fusion events involving ALK, MET, ROS1, RET, NTRK, and other targets, supporting advanced studies in cancer progression, targeted therapy research, and broader scientific discovery.
Why Choose CleanPlex NGS Sequencing Panels in the Medical Research Sector
CleanPlex Ready-To-Use and Custom NGS Panels use Paragon Genomics CleanPlex Technology, an ultra-high multiplex PCR amplicon-based targeted sequencing method for NGS. Medical research centers can select panels for TP53 analysis, pharmacogenomics studies, and lung cancer fusion detection, or request custom assays built around their specific genomic targets. Our team produces custom panels in a complete kit format that move nucleic acid samples to sequencing-ready libraries in about four weeks.
With CleanPlex NGS Sequencing Panels, you get:
- Fast Turn-Around Time: Accelerate your assay development project. Get your NGS panels in less than 4 weeks (from design acceptance to shipment).
- Cost-Effective Sequencing: Generate data with high on-target performance and coverage uniformity to minimize the cost of sequencing.
- Ultra-High Multiplexing: Multiplex up to 20,000+ amplicons per pool for large NGS panels to help you unlock new applications using a faster and simpler workflow.
- Flexible and Scalable Content: Update your custom NGS Panels as you gather new insights.
- High Performance: Jumpstart your work with NGS panels tailored to your needs. Our panels are expertly designed with high first-pass success and a high target design rate.
- High Level of Support: Receive fast and comprehensive support throughout the design and ordering process. Our PhD-level expert scientists are here to help.
Here From Our Satisfied Customers
“Cost-effectiveness, accessibility, and usability made Paragon Genomics the right fit. CleanPlex panels helped us streamline our NGS workflow, enabling our team to scale oncology testing with confidence. The uniformity and data quality are excellent, and being able to go from sample to sequencing-ready libraries in under 6 hours is a game-changer.”
Angélica Rodríguez, National Oncology Institute, PanamaI was very impressed by how well the CleanPlex SARS-CoV-2 panel worked when we evaluated it back in March. Working with Paragon Genomics, we were able to leverage the panel to quickly launch a SARS-CoV-2 whole-genome sequencing assay and used it effectively for a number of genomic epidemiology studies.”
Xiaowu Gai, PhD, Director of Bioinformatics, Children's Hospital Los AngelesParagon Genomics has streamlined our workflow, from assay design and optimization to laboratory implementation. Their expertise helped us successfully implement a fully automated process using a custom-designed CleanPlex UMI panel, enabling low variant allele frequency (VAF) detection critical for our projects. Paragon’s excellent bioinformatics services and customer support services were key to achieving our goals.”
Ian Mongrain, Director of Operations, Montreal Heart Institute - Pharmacogenomics CentreWhen we decided to choose a targeted sequencing platform, we had several choices and I am delighted that we chose Paragon Genomics. Paragon Genomics has enabled us to move our sequencing in-house with an affordable and easy-to-use product. They assisted us every step along the way from choosing the amplicons, to guiding us through library preparation to assisting with analysis. I strongly recommend their CleanPlex® amplicon-based targeted sequencing approach and could not be happier with their product.”
Elliot Stieglitz, MD, Associate Professor, University of California San FranciscoWe’re using Paragon’s CleanPlex and CleanPlex UMI technologies to sequence RNA viruses. These technologies enable us to rapidly and cost-effectively obtain complete viral genomes from clinical samples with low viral content. Further analyses of viral genomes, including the identification of minor variants, elucidates viral diversity and evolution. Paragon has enthusiastically worked with us to tackle this new application; they have diligently designed panels to our specifications, meeting with us frequently to optimize the design.”
Aaron Lin, PhD; Erica Normandin; Kim Lagerborg, The Broad Institute of MIT and HarvardParagon Genomics designed a high-quality NGS custom panel for us within two weeks. Its CleanPlex® targeted library technology is fast and easy to use with great PCR uniformity and on-target rate. We are very satisfied by CleanPlex product performance and the superb technical and customer support provided by the Company.”
Chongjian Chen, PhD, CEO, AnnoroadWe are looking for a ‘future proof method’, a better way to do high throughput screening at a species level diagnosis. Paragon Genomics has developed a rapid 2.5-hour library preparation allowing multi-gene methodology, letting us look at lots of unique loci across multiple genomes. It offers a ‘one and done’ approach instead of many different disconnected experiments.”
Scott Geib, PhD, Research Entomologist, USDA-ARS