CleanPlex® Hereditary Renal / Urinary Cancer Panel

The CleanPlex® Hereditary Renal / Urinary Cancer Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 28 genes associated with Hereditary Renal / Urinary Cancer.

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Product Description

The CleanPlex® Hereditary Renal / Urinary Cancer Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 28 genes associated with Hereditary Renal / Urinary Cancer. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
BAP1, CDC73, CDKN1C, DICER1, DIS3L2, EPCAM, FH, FLCN, GPC3, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, REST, SDHA, SDHB, SDHC, SDHD, SMARCA4, SMARCB1, TP53, TSC1, TSC2, VHL, WT1

References:
Hartnan et al. 2009. The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis.

Coleman et al. Hereditary and familial kidney cancer. 2009. PubMed ID: 19584731

Orlova et al. The tuberous sclerosis complex. 2010. PubMed ID: 20146692

Maher et al. von Hippel-Lindau disease: a clinical and scientific review. 2011. PubMed ID: 21386872

Lubas et al. Exonuclease hDIS3L2 specifies an exosome-independent 3′-5′ degradation pathway of human cytoplasmic mRNA. 2013. PubMed ID: 23756462

Additional Information

Weight40 g
Dimensions10 x 7 x 5 cm
Pack Size (Reactions)

384

For early access to our upcoming Respiratory Research Panel combining Influenza A/B and SARS-CoV-2 testing, please visit HERE. Dismiss