The CleanPlex® Congenital Myopathy Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 33 genes associated with Congenital Myopathy.
CleanPlex® Congenital Myopathy Panel
The CleanPlex® Congenital Myopathy Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 33 genes associated with Congenital Myopathy. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
ACTA1, BIN1, CCDC78, CCDC78, CFL2, CFL2, CHKB, CNTN1, COL12A1, COL6A1, COL6A2, COL6A3, DNM2, KBTBD13, KLHL40, KLHL41, LMOD3, MEGF10, MTM1, MYF6, MYH2, MYH7, NEB, RYR1, SCN4A, SELENON, SEPN1, SPEG, STAC3, TNNT1, TPM2, TPM3, TTN
Kuhn M, et al. Utility of a next-generation sequencing-based gene panel investigation in German patients with genetically unclassified limb-girdle muscular dystrophy. J Neurol 263, 743–750 (2016).
Kress W, et al. The Genetic Approach: Next-Generation Sequencing-Based Diagnosis of Congenital and Infantile Myopathies/Muscle Dystrophies. Neuropediatrics 2017; 48(04): 242-246.
Cassandrini D, et al. Congenital Myopathies: clinical phenotypes and new diagnostic tools. Ital J Pediatr. 2017 Nov 15;43(1):101.
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|