CleanPlex® Hypophosphatemic Rickets Panel

The CleanPlex® Hypophosphatemic Rickets Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 15 genes associated with Hypophosphatemic Rickets.

Product Description

The CleanPlex® Hypophosphatemic Rickets Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 15 genes associated with Hypophosphatemic Rickets. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
ALPL, CLCN5, CYP27B1, CYP2R1, DMP1, ENPP1, FAH, FAM20C, FGF23, FGFR1, KL, PHEX, SLC34A1, SLC34A3, VDR

References:
Lin X, et al. Genetic analysis of three families with X-linked dominant hypophosphatemic rickets. Journal of Pediatric Endocrinology and Metabolism. 2018;31(7).

Bai Y, et al. Mutation analysis of four pedigrees affected with hypophosphatemic rickets through targeted next-generation sequencing. Chinese Journal of Medical Genetics. 2018 Oct;35(5):638-643.

Lal D, et al. Increased Probability of Co-Occurrence of Two Rare Diseases in Consanguineous Families and Resolution of a Complex Phenotype by Next Generation Sequencing. Plos One. 2016;11(1):e0146040.

Additional Information

Weight40 g
Dimensions10 x 7 x 5 cm
Pack Size (Reactions)

384