The CleanPlex® Heterotaxy and Situs Inversus Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 31 genes associated with Heterotaxy and Situs Inversus.
CleanPlex® Heterotaxy and Situs Inversus Panel
The CleanPlex® Heterotaxy and Situs Inversus Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 31 genes associated with Heterotaxy and Situs Inversus. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
ACVR2B, ARMC4, C21ORF59, CCDC103, CCDC114, CCDC151, CCDC39, CCDC40, CFAP53, DNAAF1, DNAAF2, DNAAF3, DNAAF5, DNAH11, DNAH5, DNAI1, DNAI2, DNAL1, DYX1C1, FOXH1, GDF1, INVS, LEFTY2, LRRC6, MMP21, NODAL, PIH1D3, PKD1L1, SPAG1, ZIC3, ZMYND10
Zhang W, et al. Whole-exome sequencing identifies a novel CCDC151 mutation, c.325G>T (p.E109X), in a patient with primary ciliary dyskinesia and situs inversus. J Hum Genet 64, 249–252 (2019)
Cowan J, et al. Copy number variation as a genetic basis for heterotaxy and heterotaxy-spectrum congenital heart defects. Philos Trans R Soc Lond B Biol Sci. 2016 Dec 19;371(1710).
Robinson PJ, et al. Situs inversus: When an incidental finding is not so incidental. Paediatr Child Health. 2017 Jul;53(7):715-716.
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|