The CleanPlex® Common Variable Immunodeficiency (CVID) Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 25 genes associated with Common Variable Immunodeficiency (CVID).
CleanPlex® Common Variable Immunodeficiency (CVID) Panel
The CleanPlex® Common Variable Immunodeficiency (CVID) Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 25 genes associated with Common Variable Immunodeficiency (CVID). The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.
This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.
Store at -20 °C.
For Research Use Only. Not for use in diagnostic procedures.
CD19, CD27, CD81, CR2, CTLA4, ICOS, IKZF1, IL21, IL21R, IRF2BP2, LRBA, MS4A1, NFKB1, NFKB2, PIK3CD, PIK3R1, PLCG2, PRKCD, RAC2, STAT3, TNFRSF13B, TNFRSF13C, TNFSF12, TTC37, VAV1
Kienzler AK, et al. The role of genomics in common variable immunodeficiency disorders. Clinical & Experimental Immunology. 2017;188(3):326-332.
AmeratungaR , et al. Review: Diagnosing Common Variable Immunodeficiency Disorder in the Era of Genome Sequencing. Clinic Rev Allerg Immunol 54, 261–268 (2018).
|Dimensions||10 x 7 x 5 cm|
|Pack Size (Reactions)|