Paragon Genomics Introduces CleanPlex® SARS-CoV-2 NGS Panel for Research and Surveillance of COVID-19 Coronavirus

  • Highly Multiplexed Target Enrichment Panel Covers Entire Genome of the New Coronavirus to Facilitate Complete Genome Sequencing and Support Epidemiological Studies
  • CleanPlex Technology Converts Viral RNA to Sequence-Ready Libraries with Excellent Sensitivity in Just 5 Hours Using a Streamlined and Efficient Workflow

HAYWARD, CA – March 19, 2020 – Paragon Genomics, Inc., a leader in amplicon-based target enrichment solutions for next-generation sequencing (NGS) and precision medicine, today announced availability of its CleanPlex® SARS-CoV-2 Panel for COVID-19 coronavirus detection, tracking and research via amplicon-based target enrichment for NGS applications. The highly multiplexed target enrichment panel covers the entire genome of the SARS-CoV-2 virus that is responsible for the global COVID-19 pandemic, enabling complete genome sequencing and epidemiological studies of this dangerous new pathogen.

The CleanPlex SARS-CoV-2 Panel’s four-step workflow converts viral RNA into sequencing-ready libraries in just five hours. It is powered by Paragon Genomics’ CleanPlex technology, which uses a proprietary multiplex PCR background cleaning chemistry to effectively remove non-specific PCR products, resulting in best-in-class target enrichment performance and efficient use of sequencing reads.

Versions of the panel are available for both the Illumina and MGI sequencing platforms.

Paragon Genomics CEO Tao Chen commented, “It is imperative that researchers learn more about the SARS-CoV-2 virus if we are to mount effective campaigns to treat and prevent it. Our CleanPlex target enrichment technology is well suited to support this effort. It greatly facilitates genomic studies of the virus, rapidly converting viral RNA into sequencing-ready libraries in a few hours’ time using a streamlined, efficient and cost-effective workflow that works well with low viral loads.”

Mr. Chen added, “We know this virus rapidly mutates so we ensured the new panel provides high coverage of target regions to provide sensitive detection in the presence of mutations. With sequencing, these mutations can also be tracked to study the path of infection and examine different strains. Our testing shows the panel achieves superb performance with sensitivity superior to traditional qPCR methods. We believe the CleanPlex SARS-CoV-2 Panel can contribute to global efforts to control and contain this devastating new disease, and I want to acknowledge the outstanding work of our researchers who developed and validated the panel in record time.”

Paragon Genomics’ CleanPlex is a proprietary, ultra-high multiplexed NGS target enrichment technology featuring an innovative PCR background cleaning chemistry that allows tens of thousands of amplicons to be multiplexed in a single reaction pool, allowing a large number of targets to be interrogated in a single assay. The CleanPlex technology is available as ready-to-use panels or as customized assays designed and optimized using the company’s advanced panel design algorithm.

For more information on the Paragon Genomics CleanPlex SARS-CoV-2 Panel, visit

The CleanPlex SARS-CoV-2 Panel is for Research Use Only. It is not intended for disease diagnosis.

About Paragon Genomics

Paragon Genomics ( is a leader in amplicon-based target enrichment and library preparation solutions to accelerate the development of next-generation sequencing (NGS)-based assays for research and clinical testing. The company designs high performance and ultra-multiplexed amplicon NGS panels and develops NGS library preparation chemistries for analyzing difficult, clinically-relevant samples. It strives to make the design of custom NGS assays easily available to a broad range of users, with expert counsel and rapid turnaround. Privately-held Paragon Genomics is located in Hayward, California.