CleanPlex® Pan Aortopathy and Connective Tissue Disorders Panel

The CleanPlex® Pan Aortopathy and Connective Tissue Disorders Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 38 genes associated with Pan Aortopathy and Connective Tissue Disorders.

Product Description

The CleanPlex® Pan Aortopathy and Connective Tissue Disorders Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 38 genes associated with Pan Aortopathy and Connective Tissue Disorders. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
ABCC6, ACTA2, ADAMTS2, ALDH18A1, B3GAT3, BGN, CBS, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, CRTAP, EFEMP2, ELN, FBLN5, FBN1, FBN2, FKBP14, FLNA, FOXE3, LOX, MAT2A, MED12, MFAP5, MYH11, MYLK, NOTCH1, PLOD1, SKI, SLC2A10, SLC39A13, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2

References:
Pinard A, et al. Genetics of Thoracic and Abdominal Aortic Diseases. Circulation Research. 2019 Feb;124:588–606.

Overwater E, et al. Results of next‐generation sequencing gene panel diagnostics including copy‐number variation analysis in 810 patients suspected of heritable thoracic aortic disorders. Hum Mutat. 2018 Sep; 39(9): 1173–1192.

Additional Information

Weight40 g
Dimensions10 x 7 x 5 cm
Pack Size (Reactions)

384