CleanPlex® Amyotrophic Lateral Sclerosis Panel

The CleanPlex® Amyotrophic Lateral Sclerosis Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing assay for examining the germline variants or mutations across 26 genes associated with Amyotrophic Lateral Sclerosis.

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Product Description

The CleanPlex® Amyotrophic Lateral Sclerosis Panel is a pre-designed and made-to-order multiplex PCR / amplicon-based targeted sequencing (NGS) assay designed to examine the germline variants or mutations across 26 genes associated with Amyotrophic Lateral Sclerosis. The panel targets all the exonic regions of those genes and the flanking intronic sequences. Compatible with just 10 ng of DNA, sequencing-ready libraries can be prepared using a streamlined workflow in just 3 hours. The pre-designed panel is optimized in silico to deliver data with high on-target performance and high coverage uniformity to ensure efficient use of sequencing reads.

This product is made to order. Once we receive your order, we will synthesize the panel and the kit will contain CleanPlex Multiplex PCR Primers and CleanPlex Targeted Library Kit. CleanPlex Indexed PCR Primers and CleanMag® Magnetic Beads can be ordered separately to complete the workflow from input DNA to sequencing-ready NGS libraries.

Storage Temperature

Store at -20 °C.

For Research Use Only. Not for use in diagnostic procedures.

Gene List:
ALS2, ANG, C9ORF72, CHCHD10, CHMP2B, DCTN1, FIG4, FUS, GRN, HNRNPA1, KIF5A, MATR3, OPTN, PFN1, SETX, SLC52A2, SLC52A3, SOD1, SPG11, SPG20, SQSTM1, TARDBP, TBK1, UBQLN2, VAPB, VCP

References:
Nishiyama A, et al. Comprehensive targeted next-generation sequencing in Japanese familial amyotrophic lateral sclerosis. Neurobiology of Aging. 2017;53:194.e1-194.e8

De Felice B, et al. Wide-Ranging Analysis of MicroRNA Profiles in Sporadic Amyotrophic Lateral Sclerosis Using Next-Generation Sequencing. Fronteirs in Genetics. 2018.

Van Giau V, et al. Gene panels and primers for next generation sequencing studies on neurodegenerative disorders. Mol. Cell. Toxicol. (2015) 11: 89.

Additional Information

Weight40 g
Dimensions10 x 7 x 5 cm
Pack Size (Reactions)

384

For early access to our upcoming Respiratory Research Panel combining Influenza A/B and SARS-CoV-2 testing, please visit HERE. Dismiss