CleanPlex® technologies power diagnostic laboratory workflows with the rigor needed for clinical applications. Combining high sensitivity with streamlined protocols, CleanPlex enables reliable detection of variants even in challenging samples. Flexible customization and lab-validated panels support a wide range of diagnostic needs, helping laboratories deliver accurate results with speed and efficiency.
Products Most Used in Diagnostic Laboratories
OncoZoom & Hereditary Cancer Panels
Target clinically relevant hotspots and inherited risk genes with CleanPlex OncoZoom panels designed to support oncology and hereditary cancer testing. Optimized for sensitivity and reliability, they provide actionable insights for diagnostic workflows.
Custom Diagnostic Panels
Customize CleanPlex panels to the specific needs of your lab, with support for somatic variants, CNVs, fusions, and gene expression assays. Rapid design support helps panels fit seamlessly into diagnostic applications.
CleanPlex UMI Panels
Leverage UMI-based to confidently detect low-frequency variants allele frequency (VAF) mutations. Ideal for applications requiring high sensitivity, including liquid biopsy and minimal residual disease testing.
Workflow Fit
CleanPlex integrates smoothly into your clinical lab workflows, enabling efficient movement from sample to report.
Diagnostic Target Selection
Define clinically relevant genes or variant types to include in your testing panel.
CleanPlex Custom or UMI-Enabled Prep (approximately 3 hours)
Prepare high-quality libraries in just a few hours with streamlined protocols, including UMI-enabled options for low-frequency variant detection.
Sequence & Clinical-Grade Analysis
Generate accurate sequencing data ready for downstream pipelines and reporting in a diagnostic setting.
Testimonials
“Cost-effectiveness, accessibility, and usability made Paragon Genomics the right fit. CleanPlex panels helped us streamline our NGS workflow, enabling our team to scale oncology testing with confidence. The uniformity and data quality are excellent, and being able to go from sample to sequencing-ready libraries in under 6 hours is a game-changer.”
I was very impressed by how well the CleanPlex SARS-CoV-2 panel worked when we evaluated it back in March. Working with Paragon Genomics, we were able to leverage the panel to quickly launch a SARS-CoV-2 whole-genome sequencing assay and used it effectively for a number of genomic epidemiology studies.”
Xiaowu Gai, PhD, Director of Bioinformatics, Children's Hospital Los AngelesParagon Genomics has streamlined our workflow, from assay design and optimization to laboratory implementation. Their expertise helped us successfully implement a fully automated process using a custom-designed CleanPlex UMI panel, enabling low variant allele frequency (VAF) detection critical for our projects. Paragon’s excellent bioinformatics services and customer support services were key to achieving our goals.”
Ian Mongrain, Director of Operations, Montreal Heart Institute - Pharmacogenomics CentreWhen we decided to choose a targeted sequencing platform, we had several choices and I am delighted that we chose Paragon Genomics. Paragon Genomics has enabled us to move our sequencing in-house with an affordable and easy-to-use product. They assisted us every step along the way from choosing the amplicons, to guiding us through library preparation to assisting with analysis. I strongly recommend their CleanPlex® amplicon-based targeted sequencing approach and could not be happier with their product.”
Elliot Stieglitz, MD, Associate Professor, University of California San FranciscoWe’re using Paragon’s CleanPlex and CleanPlex UMI technologies to sequence RNA viruses. These technologies enable us to rapidly and cost-effectively obtain complete viral genomes from clinical samples with low viral content. Further analyses of viral genomes, including the identification of minor variants, elucidates viral diversity and evolution. Paragon has enthusiastically worked with us to tackle this new application; they have diligently designed panels to our specifications, meeting with us frequently to optimize the design.”
Aaron Lin, PhD; Erica Normandin; Kim Lagerborg, The Broad Institute of MIT and HarvardParagon Genomics designed a high-quality NGS custom panel for us within two weeks. Its CleanPlex® targeted library technology is fast and easy to use with great PCR uniformity and on-target rate. We are very satisfied by CleanPlex product performance and the superb technical and customer support provided by the Company.”
Chongjian Chen, PhD, CEO, AnnoroadWe are looking for a ‘future proof method’, a better way to do high throughput screening at a species level diagnosis. Paragon Genomics has developed a rapid 2.5-hour library preparation allowing multi-gene methodology, letting us look at lots of unique loci across multiple genomes. It offers a ‘one and done’ approach instead of many different disconnected experiments.”
Scott Geib, PhD, Research Entomologist, USDA-ARSWhy CleanPlex for Diagnostic Laboratories?
CleanPlex delivers the accuracy and efficiency diagnostic laboratories need to keep pace with clinical demands. Its ultra-sensitive amplicon sequencing and low background noise support the detection of variants with clinical-grade confidence.
With broad compatibility across major sequencing platforms, CleanPlex integrates seamlessly into existing lab infrastructure, avoiding costly changes or workflow disruptions.
A streamlined preparation process and consistently high uniformity enable faster turnaround and greater throughput, while lowering overall sequencing costs helping laboratories deliver reliable results more efficiently.
