ParagonDesigner™ simplifies your targeted sequencing panel design, giving you instant insights into amplicon coverage for your genes or genomic regions. Easily query pre-designed genes, submit custom panel requests, and get expert support to refine your assays with precision.

How To Submit Your Design Using Our Online Portal

1. Create an Account

2. Select Your Design Parameters

  • Chemistry Selection: Choose CleanPlex, CleanPlex UMI (with molecular barcodes) or AgriType, depending on your application.
  • Organism of Interest: Select the relevant reference genome (e.g., human hg19 or hg38).
  • Design Type: Choose either Hotspot (SNP) or Region-based design.
  • Amplicon Size: Standard size is 275bp, though other options are available.
  • Target Material: Select whether your design is for DNA or RNA.
  • NGS Platform & Read Length: Specify the platform and read length required for sequencing.

3. Enter Target Information

  • Provide a list of gene symbols manually or upload a .txt BED file (guidance is available on the portal).

4. Submit Your Design

  • Name your design and provide a description.
  • Fill in project and contact details.
  • Read and accept the Design Service Agreement.
  • Click “Submit Design.”

5. Review & Approval Process

  • A design ID will be assigned upon submission.
  • You will receive a notification when the design is ready. Simple designs are typically ready within a few days. More complex designs can take up to two weeks.
  • Review your design package and approve or request modifications before synthesis begins.

6. Modifications & Final Approval

  • Up to two free modifications are allowed before oligo synthesis.
  • Additional modifications (beyond two) require review, approval, and may incur fees.
  • To minimize delays, make sure your initial submission aligns with your final scope.

7. Oligo Synthesis & Turnaround Time

  • Once synthesis begins, panels typically ship within three to four weeks.

Questions?

Reach out to our support team at [email protected]