Technical Note – A High-Performance Solution Combining CleanPlex® OncoZoom® Cancer Hotspot Panel and SOPHiATM AI for Rapid Chararcterization of Somatic Mutations

The expert team at SOPHiA GENETICS compared the performance of CleanPlex OncoZoom Cancer Hotspot Panel to three other commercially-available amplicon-based cancer hotspot panels using DNA samples of varying quality and quantity extracted from FFPE tissues. They found that Paragon Genomics’ CleanPlex OncoZoom Cancer Hotspot Panel provided the highest coverage uniformity and produced a high library conversion rate. When combined with SOPHiA for genomic analysis, the panel’s high quality data enabled accurate and reproducible variant detection.