With ultra-sensitive amplicon sequencing and a streamlined, approximately 3-hour workflow, researchers can generate high-quality data quickly and cost-effectively. This enables efficient biomarker evaluation, pharmacogene screening, and assay development that keep pace with modern R&D demands.
Products Most Used in Pharma & Biotech
CleanPlex Pharmacogenomics (PGx) Kit
The CleanPlex PGx Kit provides comprehensive coverage of 28 key pharmacogenes in a single, streamlined assay. With approximately 3-hour library prep and built-in CNV detection, it delivers actionable insights into how genetic variation influences drug metabolism, efficacy, and toxicity.
Custom CleanPlex Panels (Pharma Projects)
When your projects demand flexibility, CleanPlex Custom Panels enable researchers to target specific gene families, biomarkers, or variant sets relevant to drug development pipelines. Our expert team provides design review and scalable solutions customized to the unique needs of pharmaceutical and biotech studies. For pharmacogenomics profiling, CleanPlex Custom Panels offer you a reliable path from concept to production.
Workflow Fit
Our solutions for pharma and biotech integrate seamlessly into existing NGS pipelines, making it easier to move from concept to data generation in a single day.
Gene Selection
Identify the pharmacogenes or biomarker targets most relevant to your project, from drug metabolism pathways to variant sets linked with efficacy or toxicity.
CleanPlex® PGx or Custom Design
Choose the ready-to-use CleanPlex PGx Kit for broad coverage of 28 pharmacogenes, or collaborate with our experts to create a custom panel that aligns with your specific research needs.
Library Preparation (~3 hours)
Generate high-quality sequencing libraries quickly with a streamlined, single-tube workflow designed for efficiency and low DNA input.
Sequence & Analyze
Leverage compatibility with major sequencing platforms to detect pharmacogenomic markers, identify biomarkers, and accelerate downstream analysis with confidence.
Testimonials
“Cost-effectiveness, accessibility, and usability made Paragon Genomics the right fit. CleanPlex panels helped us streamline our NGS workflow, enabling our team to scale oncology testing with confidence. The uniformity and data quality are excellent, and being able to go from sample to sequencing-ready libraries in under 6 hours is a game-changer.”
I was very impressed by how well the CleanPlex SARS-CoV-2 panel worked when we evaluated it back in March. Working with Paragon Genomics, we were able to leverage the panel to quickly launch a SARS-CoV-2 whole-genome sequencing assay and used it effectively for a number of genomic epidemiology studies.”
Xiaowu Gai, PhD, Director of Bioinformatics, Children's Hospital Los AngelesParagon Genomics has streamlined our workflow, from assay design and optimization to laboratory implementation. Their expertise helped us successfully implement a fully automated process using a custom-designed CleanPlex UMI panel, enabling low variant allele frequency (VAF) detection critical for our projects. Paragon’s excellent bioinformatics services and customer support services were key to achieving our goals.”
Ian Mongrain, Director of Operations, Montreal Heart Institute - Pharmacogenomics CentreWhen we decided to choose a targeted sequencing platform, we had several choices and I am delighted that we chose Paragon Genomics. Paragon Genomics has enabled us to move our sequencing in-house with an affordable and easy-to-use product. They assisted us every step along the way from choosing the amplicons, to guiding us through library preparation to assisting with analysis. I strongly recommend their CleanPlex® amplicon-based targeted sequencing approach and could not be happier with their product.”
Elliot Stieglitz, MD, Associate Professor, University of California San FranciscoWe’re using Paragon’s CleanPlex and CleanPlex UMI technologies to sequence RNA viruses. These technologies enable us to rapidly and cost-effectively obtain complete viral genomes from clinical samples with low viral content. Further analyses of viral genomes, including the identification of minor variants, elucidates viral diversity and evolution. Paragon has enthusiastically worked with us to tackle this new application; they have diligently designed panels to our specifications, meeting with us frequently to optimize the design.”
Aaron Lin, PhD; Erica Normandin; Kim Lagerborg, The Broad Institute of MIT and HarvardParagon Genomics designed a high-quality NGS custom panel for us within two weeks. Its CleanPlex® targeted library technology is fast and easy to use with great PCR uniformity and on-target rate. We are very satisfied by CleanPlex product performance and the superb technical and customer support provided by the Company.”
Chongjian Chen, PhD, CEO, AnnoroadWe are looking for a ‘future proof method’, a better way to do high throughput screening at a species level diagnosis. Paragon Genomics has developed a rapid 2.5-hour library preparation allowing multi-gene methodology, letting us look at lots of unique loci across multiple genomes. It offers a ‘one and done’ approach instead of many different disconnected experiments.”
Scott Geib, PhD, Research Entomologist, USDA-ARSWhy CleanPlex for Pharma & Biotech?
CleanPlex® Technology delivers the efficiency and flexibility needed to support pharmaceutical and biotech research. With robust multiplexing and compatibility across Illumina, Ion Torrent, and MGI platforms, it provides a seamless fit for diverse R&D pipelines.
High coverage uniformity and low background noise reduce false variant calls, lower sequencing costs, and increase confidence in results. These advantages make CleanPlex a reliable choice for applications ranging from CNV detection and pharmacogenomics profiling to biomarker discovery and validation.
