Customer Success Stories 2018-05-21T17:03:22+00:00

Customer Success Stories

High performance NGS panel for every application

At Paragon Genomics, we understand that every researcher and assay developer has different challenges and requirements. This is why we offer the highest level of flexibility to our customers to support their specific applications. Most importantly, we deliver high quality custom NGS panels to help customers accomplish what they set out to do, whether it’s answering a research question, replacing an existing laborious hybrid-capture workflow, or deploying a new genetic test.

Here we highlight some of the custom NGS panels we have delivered to our customers to showcase our design capabilities. 

Customer ApplicationDesign Challenges and RequirementsCleanPlex® Custom Panel Delivered
Tumor Profiling 
  • Large oncology gene panel
  • Coding sequence of 365 genes
  • Short amplicon size (105 bp – 120 bp)
  • ~1.1 Mb covered by ~19,800 amplicons
  • > 91% target design rate
Early Cancer Detection
  • Molecular barcoding
  • Ultra-sensitive detection of cancerous mutations (MSI) from biofluid
  • ~10 amplicons
  • 100% target design rate
Mithochondrial Disease
  • All 37 genes of the mitochrondria circular genome
  • ~17 kb covered by ~110 amplicons
  • 100% target design rate
Non-Invasive Prenatal Screening
  •  700+ hotspots plus regions to distinguish gender
  • cfDNA compatible
  • 5 kb panel covered by ~740 amplicons
  • > 99.8% target design rate
Infectious Disease
  • Bacterial detection and strain identifications
  • >1,000 references per loci.
  • High interspecific variations and homology
  • > 95% target design rate
Immune Repertoire Profiling
  • Quantitative profiling of tens of thousands of targets of unknown reference
  • 2 amplicons
Methylation Analysis
  • Extremely low GC content due to bisulfite treatment
  • ~1 kb covered by ~730 amplicons
  • > 98% target design rate
 AgBio
  • 20,000 genetic loci on a highly repetitive genome
  • ~19 kb covered by ~15,000 amplicons
  • > 95% target design rate

 

Hear from our customers

One of the top three commercial NGS labs in China

Application: Cancer Testing

Challenge: Uniformity and on-target rate of NGS libraries

Paragon Genomics designed a high-quality NGS custom panel for us within two weeks. Its CleanPlex® targeted library technology is fast and easy to use with great PCR uniformity and on-target rate. We are very satisfied by CleanPlex product performance and the superb technical and customer support provided by the Company.

Dr. Chongjian Chen
CEO, Annoroad

One of the major NGS service
providers in Turkey

Application: Inherited Disease Testing

Challenge: Turn-around time of custom NGS panels

As a service provider and distributor company, it is crucial for us to fulfill inquiries coming from our customer in a fast and reliable manner. Paragon Genomics’ custom design and production pipeline has shown itself very useful to expand our portfolio and services in a very short time. Their CleanPlex® assays are robust and work directly from the start with a uniform coverage distribution and the ability to design single gene or small gene panels as well as larger panels makes CleanPlex a flexible tool.

Damla Erdogan
Business Development Manager, Gen Era Diagnostics

Application: AgBio

Challenge: Quality DNA samples

We are looking for a ‘future proof method’, a better way to do high throughput screening at a species level diagnosis. Paragon Genomics has developed a rapid 2.5-hour library preparation allowing multi-gene methodology, letting us look at lots of unique loci across multiple genomes. It offers a ‘one and done’ approach instead of many different disconnected experiments.

Dr. Scott Geib
Research Entomologist, USDA-ARS

Fruit and vegetable industries in the continental US are under constant threat by invasive pest fruit flies, many of which cannot be identified using morphology alone. When flies or their larvae are intercepted, regulatory agencies need to quickly identify what species they are dealing with and where they came from. USDA-ARS and University of Hawaii are developing genomic tools for these tasks. Paragon Genomics’ CleanPlex® technology allows us to target thousands of highly-informative genomic regions is a single panel, thus integrating species identification and source determination. The 2.5-hour library preparation time combined with robust reaction chemistry for low quality samples means that these tools can be used quickly and efficiently.

Dr. Julian R. Dupuis
Junior Faculty, University of Hawaii at Manoa and USDA-ARS

Build your own NGS panel

Have a project in mind? Submit your request to obtain a quote. Be ready to provide details on your targets, sample type, etc.

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